Musculoskeletal Complications of Severe Acute Respiratory Syndrome
Publication in refereed journal


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摘要The severe acute respiratory syndrome (SARS) was a highly infectious pneumonia that emerged in southern China early in 2003. A large number of SARS patients experienced large joint arthralgia, although this was, for the most part, not associated with any abnormality on magnetic resonance imaging. The main musculoskeletal complications of SARS were osteonecrosis and reduced bone mass, and these arose not from the disease per se but as a sequel to treatment of SARS with high-dose steroids. SARS patients were almost universally steroid naive with no other known predisposition to osteonecrosis. Prevalence of osteonecrosis in SARS patients treated with steroids ranged from 5% to 58%. Ostconecrosis most commonly affected the proximal femur and femoral condyles and was most strongly related to cumulative steroid dose and duration of steroid therapy. Osteonecrosis risk was <1% in patients receiving <3 g and 13% in patients receiving >3 g cumulative prcdnisolone-equivalent dose. Most osteonecrotic lesions tended to improve with a reduction in lesion volume over a follow-up period of 5 years. The relative reduction in osteonecrotic lesion volume was greatest for smaller lesions.
著者Griffith JF
期刊名稱Seminars in Musculoskeletal Radiology
出版年份2011
月份11
日期1
卷號15
期次5
出版社Thieme Publishing / Georg Thieme Verlag
頁次554 - 560
國際標準期刊號1089-7860
電子國際標準期刊號1098-898X
語言英式英語
關鍵詞Bone infarcts; osteonecrosis; osteoporosis; SARS; steroids
Web of Science 學科類別Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

上次更新時間 2021-19-01 於 00:23