CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer
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摘要Background: The CHD5 gene located on 1p36 encodes a protein - chromodomain helicase DNA-binding protein 5. CHD5 has been shown to be a tumor suppressor gene candidate. This study investigated the involvement of CHD5 in ovarian cancer and its clinicopathological significance. Methods: CHD5 expression in ovarian cancer and its counterpart were determined by quantitative RT-PCR. The correlation of CHD5 expression to clinicopathological features of the tumor was analyzed. Results: CHD5 expression was downregulated by at least twofold in 32 of 72 (41%) invasive epithelial ovarian carcinomas when compared to 12 controls in Hong Kong Chinese women. CHD5 downregulation was correlated to clinical status (p < 0.05), but not to patient age, tumor type and grade, recurrence and clinical stage (p > 0.05). Survival analysis showed that patients with CHD5 downregulation in their tumors were associated with shorter disease-free and total survival times compared to those without CHD5 downregulation (p < 0.05). Cox proportional-hazards regression analysis indicated that downregulation of CHD5 is an independent adverse prognostic factor in ovarian cancer. Conclusion: This study shows that CHD5 is downregulated in a certain number of ovarian cancers and appears to be an adverse predictor candidate of ovarian cancer disease-free and total survival. Copyright (C) 2011 S. Karger AG, Basel
著者Wong RRY, Chan LKY, Tsang TPT, Lee CWS, Cheung TH, Yim SF, Siu NSS, Lee SNC, Yu MY, Chim SSC, Wong YF, Chung TKH
期刊名稱Gynecologic and Obstetric Investigation
出版年份2011
月份1
日期1
卷號72
期次3
出版社Karger Publishers
頁次203 - 207
國際標準期刊號0378-7346
電子國際標準期刊號1423-002X
語言英式英語
關鍵詞CHD5; Downregulation; Ovarian cancer
Web of Science 學科類別Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

上次更新時間 2020-24-11 於 00:18