CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer
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AbstractBackground: The CHD5 gene located on 1p36 encodes a protein - chromodomain helicase DNA-binding protein 5. CHD5 has been shown to be a tumor suppressor gene candidate. This study investigated the involvement of CHD5 in ovarian cancer and its clinicopathological significance. Methods: CHD5 expression in ovarian cancer and its counterpart were determined by quantitative RT-PCR. The correlation of CHD5 expression to clinicopathological features of the tumor was analyzed. Results: CHD5 expression was downregulated by at least twofold in 32 of 72 (41%) invasive epithelial ovarian carcinomas when compared to 12 controls in Hong Kong Chinese women. CHD5 downregulation was correlated to clinical status (p < 0.05), but not to patient age, tumor type and grade, recurrence and clinical stage (p > 0.05). Survival analysis showed that patients with CHD5 downregulation in their tumors were associated with shorter disease-free and total survival times compared to those without CHD5 downregulation (p < 0.05). Cox proportional-hazards regression analysis indicated that downregulation of CHD5 is an independent adverse prognostic factor in ovarian cancer. Conclusion: This study shows that CHD5 is downregulated in a certain number of ovarian cancers and appears to be an adverse predictor candidate of ovarian cancer disease-free and total survival. Copyright (C) 2011 S. Karger AG, Basel
All Author(s) ListWong RRY, Chan LKY, Tsang TPT, Lee CWS, Cheung TH, Yim SF, Siu NSS, Lee SNC, Yu MY, Chim SSC, Wong YF, Chung TKH
Journal nameGynecologic and Obstetric Investigation
Volume Number72
Issue Number3
PublisherKarger Publishers
Pages203 - 207
LanguagesEnglish-United Kingdom
KeywordsCHD5; Downregulation; Ovarian cancer
Web of Science Subject CategoriesObstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

Last updated on 2020-24-10 at 01:37