Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities
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摘要In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC(50) < 5 mu g ml(-1). These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin.
著者Kok SHL, Lam WS, Chan ASC, Wong WY, Gambari R, Wong RSM, Lee KKH, Tang JCO, Lam KH, Chui CH
期刊名稱MedChemComm
出版年份2011
月份9
日期1
卷號2
期次9
出版社ROYAL SOC CHEMISTRY
頁次881 - 885
國際標準期刊號2040-2503
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2020-27-11 於 00:43