Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase
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摘要Ethnopharmacological relevance: Baicalein, the active constituent derived from Scutellaria baicalensis Georgi., has previously been shown to significantly restore the effectiveness of beta-lactam antibiotics and tetracycline against methicillin-resistant Staphylococcus aureus (MRSA). With multiple therapeutic benefits, the antibacterial actions of baicalein may also be involved in overcoming other bacterial resistance mechanisms. The aim of the present study was to further investigate antibacterial activities of baicalein in association with various antibiotics against selected Staphylococcus aureus strains with known specific drug resistance mechanisms.
著者Chan BCL, Ip M, Lau CBS, Lui SL, Jolivalt C, Ganem-Elbaz C, Litaudon M, Reiner NE, Gong HS, See RH, Fung KP, Leung PC
期刊名稱Journal of Ethnopharmacology
出版年份2011
月份9
日期1
卷號137
期次1
出版社ELSEVIER IRELAND LTD
頁次767 - 773
國際標準期刊號0378-8741
語言英式英語
關鍵詞Baicalein; Efflux; MDR; MRSA; NorA; Pyruvate kinase; Staphylococcus aureus
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

上次更新時間 2021-23-01 於 00:59