A double-blind randomised comparison of intravenous patient-controlled remifentanil with intramuscular pethidine for labour analgesia
Publication in refereed journal

香港中文大學研究人員

引用次數
替代計量分析
.

其它資訊
摘要In a prospective, double-blind, randomised controlled trial, we compared the efficacy of patient-controlled analgesia using remifentanil (25-30 mu g per bolus) with intramuscular pethidine (50-75 mg) for labour analgesia in 69 parturients. Parturients receiving patient-controlled analgesia reported less pain than those receiving intramuscular pethidine throughout the study period (p < 0.001), with maximal reduction in visual analogue pain score at 2 h after commencement of analgesia (mean (SD) 20 (17) in the patient-controlled analgesia group and 36 (22) in the intramuscular pethidine group. The median (95% CI) time to the first request for rescue analgesics was significantly longer with patient-controlled analgesia (8.0 (6.8-9.2) h) compared with intramuscular pethidine (4.9 (3.8-5.4) h, p < 0.001). Maternal satisfaction scores were also higher with remifentanil compared with intramuscular pethidine (p = 0.001). There was no report of sedation, aponea or oxygen desaturation in either group, and Apgar scores were similar between groups. We conclude that patient-controlled analgesia with remifentanil provides better labour analgesia and maternal satisfaction than intramuscular pethidine. At this dose, maternal and fetal side effects were uncommon.
著者Ng TKT, Cheng BCP, Chan WS, Lam KK, Chan MTV
期刊名稱Anaesthesia
出版年份2011
月份9
日期1
卷號66
期次9
出版社Wiley: 12 months
頁次796 - 801
國際標準期刊號0003-2409
電子國際標準期刊號1365-2044
語言英式英語
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

上次更新時間 2020-26-11 於 00:40