Differential Inhibitory Effects of CysLT(1) Receptor Antagonists on P2Y(6) Receptor-Mediated Signaling and Ion Transport in Human Bronchial Epithelia
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AbstractBackground: Cysteinyl leukotriene (CysLT) is one of the proinflammatory mediators released by the bronchi during inflammation. CysLTs exert their biological effects via specific G-protein-coupled receptors. CysLT(1) receptor antagonists are available for clinical use for the treatment of asthma. Recently, crosstalk between CysLT(1) and P2Y(6) receptors has been delineated. P2Y receptors are expressed in apical and/or basolateral membranes of virtually all polarized epithelia to control the transport of fluid and electrolytes. Previous research suggests that CysLT(1) receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. However, the detailed molecular mechanism underlying the inhibition remains unresolved.
All Author(s) ListLau WKH, Chow AWM, Au SCL, Ko WH
Journal namePLoS ONE
Detailed descriptionTo ORKTS: doi: 10.1371/journal.pone.0022363
Volume Number6
Issue Number7
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

Last updated on 2021-02-05 at 00:44