Characterization of Three Synuclein Genes in Xenopus laevis
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摘要The synuclein family consists of three small intracellular proteins mainly expressed in neural tissues, and has been associated with human neurodegenerative diseases. We have examined the spatial and temporal expression patterns of three synuclein genes during embryogenesis of Xenopus laevis. The Xenopus synucleins were firstly expressed in the developing nervous system at the tail bud stages. At tadpole stages, Xenopus snca was expressed in the brain, branchial arch and somite, and sncbb signals were detected in entire brain and spinal cord. However, sncg was only expressed in the peripheral nervous system including trigeminal nerve and dorsal root ganglion. RT-PCR indicated that expression of synucleins was up-regulated at the end of neurulation, and then maintained at later examined stages. Our study provides the spatiotemporal expression patterns of the synuclein family genes in Xenopus embryos, and forms a basis for further functional analysis of synucleins. Developmental Dynamics 240:2028-2033, 2011. (C) 2011Wiley-Liss, Inc.
著者Wang CD, Liu Y, Chan WY, Chan SO, Grunz H, Zhao H
期刊名稱Developmental Dynamics
詳細描述To ORKTS: doi:10.1002/dvdy.22693
出版年份2011
月份8
日期1
卷號240
期次8
出版社WILEY-BLACKWELL
頁次2028 - 2033
國際標準期刊號1058-8388
電子國際標準期刊號1097-0177
語言英式英語
關鍵詞expression pattern; Parkinson's disease; synuclein; Xenopus
Web of Science 學科類別Anatomy & Morphology; ANATOMY & MORPHOLOGY; Developmental Biology; DEVELOPMENTAL BIOLOGY

上次更新時間 2021-20-01 於 01:02