In vivo biocompatibility and efficacy of dexamethasone-loaded PLGA-PEG-PLGA thermogel in an alkali-burn induced corneal neovascularization disease model
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AbstractChallenges of ophthalmic drug delivery arise not only from the limited solubility of hydrophobic therapeutics, but also the restricted permeability and fast clearance of drugs due to the complex anatomy and physiology of eyes. Excellent biocompatibility of a thermosensitive polymer, PLGA-PEG-PLGA (1800-1500-1800, LA:GA ratio = 3:1), as an ophthalmic delivery system was demonstrated in our previous work. In this study, delivery of dexamethasone using this thermogel via a single subconjunctival injection for prolonged treatment was evaluated with corneal neovascularization using an alkali-burn diseased model in rat. Solubility of dexamethasone in the polymeric solution was increased by 5.2-fold and the resulting drug-loaded solution formed in situ rigid gel at body temperature. Prolonged in vitro release of dexamethasone from the gel structure was noted. Dexamethasone gel formulation was demonstrated to be more effective in reducing the burn stimulus and neovascularization in the rat diseased model. The findings suggest the PLGA-PEG-PLGA in situ gelling system can be applied for ophthalmic drug delivery to achieve sustained drug release and improved efficacy.
Acceptance Date24/08/2020
All Author(s) ListChan PS, Li QQ, Zhang BW, To KKW, Leung SRSY
Journal nameEuropean Journal of Pharmaceutics and Biopharmaceutics
Year2020
Month10
Volume Number155
PublisherELSEVIER
Pages190 - 198
ISSN0939-6411
eISSN1873-3441
LanguagesEnglish-United Kingdom
KeywordsIn situ gelling system, Sustained release, Hydrogel, Ophthalmic drug delivery, Steroids, Corneal neovascularization
Web of Science Subject CategoriesPharmacology & Pharmacy;Pharmacology & Pharmacy

Last updated on 2021-28-11 at 00:13