Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamsters
Publication in refereed journal

香港中文大學研究人員

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摘要Onion has been shown to favorably modify the lipoprotein profile. However, research on its underlying mechanism is lacking. The present study investigated the interaction of dietary onion powder with the protein expression of key receptors and enzymes involved in cholesterol metabolism. Thirty-six male hamsters were randomly divided into three groups and fed a high-cholesterol control diet or the two experimental diets supplemented with 1% onion powder (OP-1) or 5% onion powder (OP-5), for a period of 8 weeks. It was found that onion dose-dependently decreased plasma total cholesterol (TC) level. The change in plasma lipoprotein profile was accompanied by a greater excretion of both fecal neutral and acidic sterols. Western blot analysis revealed that onion up-regulated sterol regulatory clement binding protein 2 (SREBP-2), liver X receptor alpha (LXR alpha) and cholesterol-7 alpha-hydroxylase (CYP7A1) with no effect on 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and LDL receptor (LDL-R). It was concluded that the hypocholesterolemic activity of onion powder was mediated by enhancement of fecal sterol excretion and up-regulation of LXR alpha and CYP7A1.
著者Guan L, Chung HY, Su YL, Jiao R, Peng C, Chen ZY
期刊名稱Food and Function
詳細描述Vol. 1
出版年份2010
月份10
日期1
卷號1
期次1
出版社Royal Society of Chemistry
頁次84 - 89
國際標準期刊號2042-6496
電子國際標準期刊號2042-650X
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Food Science & Technology; FOOD SCIENCE & TECHNOLOGY

上次更新時間 2020-25-09 於 00:50