Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages
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摘要Pogostemonis Herba has long been used in traditional Chinese medicine for the treatment of inflammation-related disorders. Patchouli alcohol (PA) isolated from Pogostemonis Herba is a tricyclic sesquiterpene that is known to exert a variety of pharmacological activities. The present study aimed to investigate the anti-inflammatory effect of PA on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Pre-treatment with PA at concentrations of 10, 20 or 40 mu m dose-dependently decreased the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, nitric oxide (NO) and prostaglandin E(2) in LPS-stimulated RAW264.7 cells. In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1 beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells. These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1 beta, IL-6, iNOS and COX-2.
著者Xian YF, Li YC, Ip SP, Lin ZX, Lai XP, Su ZR
期刊名稱Experimental and Therapeutic Medicine
出版年份2011
月份5
日期1
卷號2
期次3
出版社Spandidos Publications
頁次545 - 550
國際標準期刊號1792-0981
電子國際標準期刊號1792-1015
語言英式英語
關鍵詞anti-inflammatory effect; lipopolysaccharide; patchouli alcohol; Pogostemonis Herba; RAW264.7 macrophages
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

上次更新時間 2020-24-11 於 00:12