Synthesis and in Vitro Photodynamic Activities of Pegylated Distyryl Boron Dipyrromethene Derivatives
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摘要A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest. photocytotoxicity with an IC(50) as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination.
著者He H, Lo PC, Yeung SL, Fong WP, Ng DKP
期刊名稱Journal of Medicinal Chemistry
出版年份2011
月份4
日期28
卷號54
期次8
出版社American Chemical Society
頁次3097 - 3102
國際標準期刊號0022-2623
電子國際標準期刊號1520-4804
語言英式英語
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2020-14-10 於 01:18