Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi
Publication in refereed journal

香港中文大學研究人員

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摘要In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 mu M to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
著者Zhang JY, Tao LY, Liang YJ, Chen LM, Mi YJ, Zheng LS, Wang F, She ZG, Lin YC, To KKW, Fu LW
期刊名稱Marine Drugs
出版年份2010
月份4
日期1
卷號8
期次4
出版社MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
頁次1469 - 1481
國際標準期刊號1660-3397
語言英式英語
關鍵詞anthracenedione derivatives; anticancer; apoptosis; mangrove endophytic fungi; structure-activity relationship
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2021-17-09 於 01:11