Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
Publication in refereed journal

香港中文大學研究人員

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摘要Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives.
著者Tao LY, Zhang JY, Liang YJ, Chen LM, Zheng LS, Wang F, Mi YJ, She ZG, To KKW, Lin YC, Fu LW
期刊名稱Marine Drugs
出版年份2010
月份4
日期1
卷號8
期次4
出版社MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
頁次1094 - 1105
國際標準期刊號1660-3397
語言英式英語
關鍵詞isoflavone; mangrove fungi; multidrug resistance (MDR); prostaglandins; quinones; xyloketal
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2021-17-09 於 01:11