Ethanol Extract of Fructus Ligustri Lucidi Promotes Osteogenesis of Mesenchymal Stem Cells
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AbstractFructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over 1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate in the prevention and treatment of osteoporosis. The present study aimed to determine whether EFLL carries out the effect by promoting osteogenesis in mesenchymal stem cells (MSCs). The osteogenic differentiation of MSCs was evaluated by their alkaline phosphatase (ALP) activities and mineralization. Expression of genes was detected by RT-PCR. We found that EFLL significantly stimulated the ALP activities and shortened the time needed for the mineralization of MSCs during osteogenic differentiation. The expression of several osteoblast differentiation regulators was also upregulated by EFLL during this process. Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis. Copyright (C) 2009 John Wiley & Sons, Ltd.
All Author(s) ListLi G, Zhang XA, Zhang JF, Chan CY, Yew DTW, He ML, Lin MCM, Leung PC, Kung HF
Journal namePhytotherapy Research
Volume Number24
Issue Number4
PublisherWiley: 12 months
Pages571 - 576
LanguagesEnglish-United Kingdom
Keywordsbone marrow; Fructus Ligustri Lucidi; mesenchymal stem cells; osteogenesis
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-15-08 at 01:26