Distribution of melamine in rat foetuses and neonates
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摘要Pharmacokinetics of melamine has not been studied in pregnancies despite of the many reports on the effect on renal damage in adult and neonates. In this study, Sprague-Dawley rats have been used as a model to study the single-dose effect of melamine administration in late pregnancy and in neonates within 24h. Melamine concentrations in maternal serum, breast milk, whole foetus, amniotic fluid, neonatal serum and neonatal kidney was measured by liquid chromatography coupled with mass spectrometry. Melamine was detected in all the samples, including foetal rats and amniotic fluid in utero. Melamine was able to pass through placenta and reach the foetus, and to accumulate in lactating mammary gland and neonatal kidney. Moreover, melamine was eliminated through the placenta of the foetus and the kidneys of the neonates, and later excreted into the amniotic fluid. The study characterised for the first time the distribution of melamine in foetuses and neonates, providing reference for toxicological study of melamine during pregnancy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
著者Chu CY, Chu KO, Chan JYW, Liu XZ, Ho CS, Wong CK, Lau CM, Ting TL, Fok TF, Fung KP, Wang CC
期刊名稱Toxicology Letters
出版年份2010
月份12
日期15
卷號199
期次3
出版社Elsevier
頁次398 - 402
國際標準期刊號0378-4274
電子國際標準期刊號1879-3169
語言英式英語
關鍵詞Fetus; Melamine; Neonate; Pharmacokinetics; Pregnant
Web of Science 學科類別Toxicology; TOXICOLOGY

上次更新時間 2020-14-09 於 00:29