Identification of source of calcium in HeLa cells by femtosecond laser excitation
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AbstractCalcium is an important messenger in cells and whose store and diffusion dynamics at the subcellular level remain unclear. By inducing a controlled slow subcellular Ca(2+) release through femtosecond laser irradiation in HeLa cells immersed in different media, cytoplasm is identified to be the major intracellular Ca(2+) store, with the nucleus being the minor store and the extracellular Ca(2+) also contributing to the total cellular Ca(2+) level. Furthermore, Ca(2+) released in either the cytoplasm or nucleus diffuses into the nucleus or cytoplasm, respectively, at different rates and influences the Ca(2+) release in those regions. (c) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3485741]
All Author(s) ListHe H, Kong SK, Chan KT
Journal nameJournal of Biomedical Optics
Volume Number15
Issue Number5
PublisherSociety of Photo-optical Instrumentation Engineers (SPIE)
LanguagesEnglish-United Kingdom
KeywordsCa(2+) elevation; Ca(2+) wave; femtosecond laser; photostimulation
Web of Science Subject CategoriesBiochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology; Optics; OPTICS; Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Last updated on 2021-18-01 at 23:57