The analgesic efficacy of continuous wound instillation with ropivacaine after open hepatic surgery
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AbstractThe analgesic efficacy of continuous local anaesthetic wound instillation after open hepatic surgery was evaluated. Forty-eight patients scheduled for elective liver surgery were assigned to receive either ropivacaine 0.25% or saline infusion at 4 ml.h(-1) for 68 h via two multi-orifice indwelling catheters placed within the musculo-fascial layer before skin closure; plasma ropivacaine concentrations were measured during the infusion. Supplemental analgesia was provided by intravenous patient-controlled analgesia morphine. Patients in the ropivacaine group had decreased mean (SD) total morphine consumption (58 (30) mg vs 86 (44) mg, p - 0.01) and less pain at rest as well as after spirometry at 4, 12, 24, 48 and 72 h postoperatively (p < 0.01). Forced vital capacity was reduced postoperatively in both groups, but the reduction was greater in the saline group at 12 and 24 h (p = 0.03). The mean plasma concentration of ropivacaine increased to 2.05 (0.78) mu at the point when the infusion was terminated.
All Author(s) ListChan SK, Lai PB, Li PT, Wong J, Karmakar MK, Lee KF, Gin T
Journal nameAnaesthesia
Volume Number65
Issue Number12
PublisherWiley: 12 months
Pages1180 - 1186
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesAnesthesiology; ANESTHESIOLOGY

Last updated on 2022-12-01 at 23:47