Overexpression of Bax inhibitor-1 (BI-1) induces cell transformation in NIH3T3 cells
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AbstractBI-1 (Bax inhibitor-1), an apoptosis-inhibiting gene belonging to the Bcl-2 protein family, plays an important role in mitochondrial apoptosis pathway to suppress Bax-induced apoptosis. To investigate the potential role of BI-1 in promoting cell growth and tumorigenesis, in the present study we overexpressed the BI-1 gene in NIH3T3 cells using the lentivirus-mediated gene expression system. Our in vitro studies showed that NIH3T3 cells overexpressing BI-1 displayed a significantly higher growth rate and formed more and larger colonies than the control cells. In addition, our in vivo studies indicated that the lenti-BI-1-infected cells formed obvious tumours, while no tumours were formed by the control cells after subcutaneously injected into nude mice. These results strongly suggested that the BI-1 gene might play a crucial role in neoplastic genesis and development.
All Author(s) ListLi XY, Chen YC, Zhou KY, Zhang MH, Luo HQ, Kung HF, Zhou X
Journal nameCell Biology International
Detailed descriptionTo ORKTS: DOI: 10.1042/CBI20090400
Volume Number34
Issue Number11
PublisherWiley: 12 months
Pages1099 - 1104
LanguagesEnglish-United Kingdom
KeywordsBI-1; cell growth; transformation; tumorigenicity
Web of Science Subject CategoriesCell Biology; CELL BIOLOGY

Last updated on 2021-25-02 at 00:53