Overexpression of Bax inhibitor-1 (BI-1) induces cell transformation in NIH3T3 cells
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要BI-1 (Bax inhibitor-1), an apoptosis-inhibiting gene belonging to the Bcl-2 protein family, plays an important role in mitochondrial apoptosis pathway to suppress Bax-induced apoptosis. To investigate the potential role of BI-1 in promoting cell growth and tumorigenesis, in the present study we overexpressed the BI-1 gene in NIH3T3 cells using the lentivirus-mediated gene expression system. Our in vitro studies showed that NIH3T3 cells overexpressing BI-1 displayed a significantly higher growth rate and formed more and larger colonies than the control cells. In addition, our in vivo studies indicated that the lenti-BI-1-infected cells formed obvious tumours, while no tumours were formed by the control cells after subcutaneously injected into nude mice. These results strongly suggested that the BI-1 gene might play a crucial role in neoplastic genesis and development.
著者Li XY, Chen YC, Zhou KY, Zhang MH, Luo HQ, Kung HF, Zhou X
期刊名稱Cell Biology International
詳細描述To ORKTS: DOI: 10.1042/CBI20090400
出版年份2010
月份11
日期1
卷號34
期次11
出版社Wiley: 12 months
頁次1099 - 1104
國際標準期刊號1065-6995
電子國際標準期刊號1095-8355
語言英式英語
關鍵詞BI-1; cell growth; transformation; tumorigenicity
Web of Science 學科類別Cell Biology; CELL BIOLOGY

上次更新時間 2021-11-01 於 23:41