Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
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AbstractNeuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. (C) 2010 Elsevier Inc. All rights reserved.
All Author(s) ListYuan QJ, Hu B, Chu TH, Su HX, Zhang WM, So KF, Lin ZX, Wu WT
Journal nameNitric Oxide: Biology and Chemistry
Year2010
Month12
Day15
Volume Number23
Issue Number4
PublisherElsevier
Pages258 - 263
ISSN1089-8603
eISSN1089-8611
LanguagesEnglish-United Kingdom
KeywordsAxonal injury; Motoneuron; Nitric oxide synthase; Regeneration; Spinal cord
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY

Last updated on 2020-05-08 at 01:11