Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1
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摘要Interest in grape seed proanthocyanidin (GSP) as a cholesterol-lowering nutraceutical is growing. This study was to investigate the effect of GSP on blood cholesterol level and gene expression of cholesterol-regulating enzymes in Golden Syrian hamsters maintained on a 0.1% cholesterol diet. Results affirmed supplementation of 0.5% or 1.0% GSP could decrease plasma total cholesterol and triacylglycerol level. Western blot and real-time polymerase chain reaction analyses demonstrated GSP did not affect sterol regulatory element binding protein-2 and low-density lipoprotein receptor; however, it increased mRNA 3hydroxy-3-methylglutaryl coenzyme A reductase. GSP had no effect on the protein mass of liver X receptor alpha (LXR alpha) but it decreased mRNA LXR alpha. Most importantly, GSP increased not only the protein level of cholesterol-7 alpha-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of GSP was most likely mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. (C) 2010 Elsevier Inc. All rights reserved.
著者Jiao R, Zhang ZS, Yu HJ, Huang Y, Chen ZY
期刊名稱Journal of Nutritional Biochemistry
詳細描述To ORKTS: doi: 10.1016/j.jnutbio.2009.10.007
出版年份2010
月份11
日期1
卷號21
期次11
出版社Elsevier
頁次1134 - 1139
國際標準期刊號0955-2863
電子國際標準期刊號1873-4847
語言英式英語
關鍵詞Cholesterol; CYP7A1; Grape seed proanthocyanidin; HMG-CoA reductase; LDL receptor; Liver X receptor; SREBP-2
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Nutrition & Dietetics; NUTRITION & DIETETICS

上次更新時間 2021-18-01 於 23:53