Antifungal Activity of Baicalein Against Candida krusei Does Not Involve Apoptosis
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AbstractThe present study was designed to evaluate the antifungal activity of baicalein against Candida krusei isolates. Using a broth microdilution assay, baicalein exhibited potent in vitro antifungal activity against C. krusei isolates with a minimum inhibitory concentration of 2.7 mu g/ml. Flow cytometric study indicated that baicalein depolarized mitochondrial membrane potential in a concentration-dependent manner. However, mechanistic analyses showed that the intracellular reactive oxygen species (ROS) level was virtually unchanged, and massive DNA fragmentation was not observed in C. krusei isolates after baicalein treatment even at a concentration which was apoptotic in C. albicans. Taken together, we conclude that the antifungal activity of baicalein in C. krusei isolates occurs through perturbation in mitochondrial homeostasis without causing elevation of the intracellular ROS level and does not involve apoptosis.
All Author(s) ListKang K, Fong WP, Tsang PWK
Journal nameMycopathologia
Year2010
Month12
Day1
Volume Number170
Issue Number6
PublisherSpringer Verlag (Germany)
Pages391 - 396
ISSN0301-486X
LanguagesEnglish-United Kingdom
KeywordsBaicalein; Candida krusei; Mitochondrial membrane potential; Reactive oxygen species
Web of Science Subject CategoriesMycology; MYCOLOGY

Last updated on 2020-24-11 at 23:56