Antifungal Activity of Baicalein Against Candida krusei Does Not Involve Apoptosis
Publication in refereed journal

香港中文大學研究人員

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摘要The present study was designed to evaluate the antifungal activity of baicalein against Candida krusei isolates. Using a broth microdilution assay, baicalein exhibited potent in vitro antifungal activity against C. krusei isolates with a minimum inhibitory concentration of 2.7 mu g/ml. Flow cytometric study indicated that baicalein depolarized mitochondrial membrane potential in a concentration-dependent manner. However, mechanistic analyses showed that the intracellular reactive oxygen species (ROS) level was virtually unchanged, and massive DNA fragmentation was not observed in C. krusei isolates after baicalein treatment even at a concentration which was apoptotic in C. albicans. Taken together, we conclude that the antifungal activity of baicalein in C. krusei isolates occurs through perturbation in mitochondrial homeostasis without causing elevation of the intracellular ROS level and does not involve apoptosis.
著者Kang K, Fong WP, Tsang PWK
期刊名稱Mycopathologia
出版年份2010
月份12
日期1
卷號170
期次6
出版社Springer Verlag (Germany)
頁次391 - 396
國際標準期刊號0301-486X
語言英式英語
關鍵詞Baicalein; Candida krusei; Mitochondrial membrane potential; Reactive oxygen species
Web of Science 學科類別Mycology; MYCOLOGY

上次更新時間 2020-12-10 於 00:07