RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo
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摘要The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
著者Chen YC, Xie D, Li WY, Cheung CM, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJY, Kung HF
期刊名稱Cancer Letters
詳細描述To ORKTS: DOI: 10.1016/j.canlet.2010.05.003
出版年份2010
月份11
日期1
卷號297
期次1
出版社Elsevier
頁次109 - 116
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞Enhancer of zeste homolog 2; Liver metastasis; Pancreatic cancer; Tumorigenecity
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-24-10 於 00:41