RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo
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AbstractThe function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListChen YC, Xie D, Li WY, Cheung CM, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJY, Kung HF
Journal nameCancer Letters
Detailed descriptionTo ORKTS: DOI: 10.1016/j.canlet.2010.05.003
Year2010
Month11
Day1
Volume Number297
Issue Number1
PublisherElsevier
Pages109 - 116
ISSN0304-3835
eISSN1872-7980
LanguagesEnglish-United Kingdom
KeywordsEnhancer of zeste homolog 2; Liver metastasis; Pancreatic cancer; Tumorigenecity
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-22-09 at 01:27