Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication
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香港中文大學研究人員

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摘要Hepatitis B virus infection is a worldwide epidemic and is closely associated with the development of hepatocellular carcinoma. Nevertheless, the molecular mechanisms of HBV infection and carcinogenesis remain elusive. Using a hepatocyte model of HBV infection and comparing the gene expression profiling analysis we found that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 B1 (HS3ST3B1,3-OST3-B) is down-regulated in the hepatocytes of chronic HBV infection model. HS3ST3B1 showed potent inhibitory effect on HBV replication. The inhibitory effect of HS3ST3B1 overexpression was lost upon gene silencing of HS3ST3B1 or when a catalytic inactive mutant of HS3ST3B1 was expressed. Our study revealed the anti-viral activity of HS3ST3B1 on HBV replication. It is conceivable that possible therapeutic applications of HBV infection could be devised by manipulating HS3ST3B1 activity. (C) 2010 Elsevier Inc. All rights reserved.
著者Zhang ZZ, Liu XA, Chen JA, Su HB, Luo QA, Ye J, Tang N, Zhang WL, Chen WX, Ko BCB, Huang AL
期刊名稱Virology
出版年份2010
月份10
日期25
卷號406
期次2
出版社Elsevier
頁次280 - 285
國際標準期刊號0042-6822
語言英式英語
關鍵詞3-O-sulfotransferase 3 B1; Heparan sulfate D-glucosaminyl; Hepatitis B virus; Inhibition; Replication
Web of Science 學科類別Virology; VIROLOGY

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