14-3-3 sigma expression as a prognostic marker in undifferentiated nasopharyngeal carcinoma
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AbstractIn this study, we investigated the expression of 14-3-3 sigma tumor suppressor gene in a panel of NPC cell lines, xenografts and primary tumors. Our objective was to determine the correlation between 14-3-3 sigma expression and clinical outcome in NPC. We detected reduced 14-3-3 sigma expression in 5/6 NPC tumor lines by quantitative RT-PCR and Western blotting. By immunohistochemical staining, significant down-regulation of 14-3-3 sigma was also found in 26/72 (36.1%) primary tumors of NPC patients, who were treated with curative radiotherapy. Promoter methylation was confirmed in a subset of primary tumors by methylation-specific PCR analysis. Importantly, we demonstrated that 14-3-3 sigma expression is significantly associated with both overall survival (OS) and cancer-specific survival (CSS), but not with the clinical staging of NPC patients. The low 14-3-3 sigma expression was associated with improved overall (p=0.029) and cancer-specific survival (p=0.042) on univariate analysis. 14-3-3 sigma expression and staging were also independent variables to all the prognostic factors under multi-variate analysis. In conclusion, low expression of 14-3-3 sigma appears to be a valuable marker for better survival in patient with NPC. These results provide the evidence that 14-3-3 sigma expression is a significant prognostic factor for NPC patients.
All Author(s) ListChan SYY, To KF, Leung SF, Yip WWL, Mak MKF, Chung GTY, Lo KW
Journal nameOncology Reports
Volume Number24
Issue Number4
PublisherSpandidos Publications
Pages949 - 955
LanguagesEnglish-United Kingdom
Keywords14-3-3 sigma; DNA methylation; nasopharyngeal carcinoma; prognostic marker; radiotherapy
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2021-15-09 at 00:14