4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery
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AbstractThe present study aimed at examining the role of potassium channels and endothelium in relaxations induced by sodium hydrogen sulphide (NaHS), which is the donor of gaseous hydrogen sulphide (H2S) and the effect of NaHS on endothelium-dependent relaxations in rat coronary arteries. Rat coronary arteries were suspended in a myograph for force measurement and changes of the membrane potential in arteries were determined by membrane potential-sensitive fluorescence dye. NaHS relaxed coronary arteries pre-contracted by U46619 and the relaxation was significantly less in high KCl-contracted rings. NaHS-induced relaxations were reduced by 4-aminopyridine (4-AP) but unaffected by glibenclamide, iberiotoxin, N-G-nitro-L-arginine methyl ester, ODQ indomethacin or by endothelium removal. The inhibitory effect of 4-AP was absent in NaHS-induced relaxations in high KCl-contracted rings. Addition of NaHS caused membrane hyperpolarization and this effect was inhibited by 4-AP but not by glibenclamide. NaHS causes endothelium-independent relaxations in rat coronary arteries partially through activation of 4-AP-sensitive potassium channel and ensuring hyperpolarization. Other potassium channels. Na+-K+ pump or endothelium-derived relaxing factors play little role. (C) 2010 Elsevier Inc. All rights reserved.
All Author(s) ListCheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao XQ, Chen ZY, Huang Y
Journal nameVascular Pharmacology
Year2010
Month9
Day1
Volume Number53
Issue Number3-4
PublisherELSEVIER SCIENCE INC
Pages94 - 98
ISSN1537-1891
eISSN1879-3649
LanguagesEnglish-United Kingdom
KeywordsCoronary artery; Hydrogen sulphide; Potassium channel; Rat; Relaxation
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-27-10 at 00:29