Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders
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AbstractCathelicidins, a family of host defense peptides, are highly expressed during infection, inflammation and wound healing. These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in diseased tissues. In this connection, a mouse cathelicidin has been demonstrated to prevent inflammation in the colon through enhancing mucus production and reducing production of pro-inflammatory cytokines. In addition, cathelicidins promote wound healing through stimulation of re-epithelialization and angiogenesis at injured tissues. In an animal model of gastric ulceration, the rat cathelicidin promotes ulcer healing by inducing proliferation of gastric epithelial cells both in vitro and in vivo. In conclusion, cathelicidins represent an important group of effector molecules in the innate immune system that operates a complex integration of inflammation and tissue repair in the gastrointestinal mucosa and other organs.
All Author(s) ListWu WKK, Wong CCM, Li ZJ, Zhang L, Ren SX, Cho CH
Journal nameActa Pharmacologica Sinica
Detailed descriptionTo ORKTS: doi: 10.1038/aps.2010.117
Year2010
Month9
Day1
Volume Number31
Issue Number9
PublisherNature Publishing Group: Open Access Hybrid Model Option A
Pages1118 - 1122
ISSN1671-4083
eISSN1745-7254
LanguagesEnglish-United Kingdom
Keywordscathelicidin; gastrointestinal disorder; inflammation; wound healing
Web of Science Subject CategoriesChemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-29-07 at 00:16