Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity
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摘要Obstructive sleep apnea (OSA) is a common sleep and breathing disorder characterized by repeated episodes of hypoxemia. USA causes neurocognitive deficits including perception and memory impairment but the underlying mechanisms are unknown. Here we show that in a mouse model of OSA, chronic intermittent hypoxia treatment impairs both early- and late-phase long-term potentiation (LTP) in the hippocampus. In intermittent hypoxia-treated mice the excitability of CA1 neurons was reduced and hippocampal brain-derived neurotrophic factor (BDNF) was down-regulated. We further showed that exogenous application of BDNF restored the magnitude of LTP in hippocampal slices from hypoxia-treated mice. In addition, microinjection of BDNF into the brain of the hypoxic mice prevented the impairment in LTP. These data suggest that intermittent hypoxia impairs hippocampal neuronal excitability and reduces the expression of BDNF leading to deficits in LTP and memory formation. Thus, BDNF level may be a novel therapeutic target for alleviating USA-induced neurocognitive deficits. (C) 2010 Elsevier Inc. All rights reserved.
著者Xie H, Leung KL, Chen L, Chan YS, Ng PC, Fok TF, Wing YK, Ke Y, Li AM, Yung WH
期刊名稱Neurobiology of Disease
詳細描述To ORKTS: doi: 10.1016/j.nbd.2010.05.020
出版年份2010
月份10
日期1
卷號40
期次1
出版社Elsevier
頁次155 - 162
國際標準期刊號0969-9961
電子國際標準期刊號1095-953X
語言英式英語
關鍵詞BDNF; Intermittent hypoxia; LTP; Neurotrophic factor; Sleep apnea; Synaptic plasticity
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2020-18-09 於 00:50