A New and Weakly Antispasmodic Protoberberine Alkaloid from Rhizoma Coptidis
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AbstractA new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC(50) of 83.7 mu M. Copyright (C) 2010 John Wiley & Sons, Ltd.
All Author(s) ListZhao M, Xian YF, Ip SP, Fong HHS, Che CT
Journal namePhytotherapy Research
Year2010
Month9
Day1
Volume Number24
Issue Number9
PublisherWiley: 12 months
Pages1414 - 1416
ISSN0951-418X
eISSN1099-1573
LanguagesEnglish-United Kingdom
Keywordsantispasmodic activity; Coptis chinensis; protoberberine; Rhizoma Coptidis
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-07-08 at 00:26