Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: A preliminary analysis
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摘要Acetylcholinesterase (AChE) (EC. 3.1.1.7) is the acetylcholine-hydrolyzing enzyme that plays an essential role on cholinergic neurotransmission at the synapses of the brain and at the neuromuscular junctions. In order to gain insight into the molecular mechanisms of neuromuscular dysfunction associated with AChE deficiency, we have compared the RNA expression profiles of the muscles of AChE knockout mice with those of the wild-type siblings. Total RNA from the leg muscle of the mice of the wild-type and the AChE nullizygous mice were subjected to microarray analyses with Affymetrix GeneChip (R) Mouse Gene 1.0 ST Array. The pair-wise comparison of gene expression levels of the 28,853 mRNA transcripts showed that 303 genes were either up- or down-regulated by more than 2.0 folds in the AChE knockout mice. The interaction study of these differentially regulated genes indicated that some of these genes are clustered in biological functions that are related to lipid metabolism and the skeletal-muscular functions. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
著者Lin HQ, Choi R, Chan KL, Ip D, Tsim KWK, Wan DCC
會議名稱10th International Meeting on Cholinesterases
會議開始日20.09.2009
會議完結日25.09.2009
會議地點Sibenik
期刊名稱Chemico-Biological Interactions
出版年份2010
月份9
日期6
卷號187
期次1-3
出版社Elsevier
頁次120 - 123
國際標準期刊號0009-2797
電子國際標準期刊號1872-7786
語言英式英語
關鍵詞AChE deficient mice; Gene profiling; Microarray analysis
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Toxicology; TOXICOLOGY

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