Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension
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摘要Some plant-based diets lower the cardiometabolic risks and prevalence of hypertension. New evidence implies a role for the transient receptor potential vanilloid 1 (TRPV1) cation channel in the pathogenesis of cardiometabolic diseases. Little is known about impact of chronic TRPV1 activation on the regulation of vascular function and blood pressure. Here we report that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A (PKA) and eNOS and thus production of nitric oxide (NO) in endothelial cells, which is calcium dependent. TRPV1 activation by capsaicin enhances endothelium-dependent relaxation in wild-type mice, an effect absent in TRPV1-deficient mice. Long-term stimulation of TRPV1 can activate PKA, which contributes to increased eNOS phosphorylation, improves vasorelaxation, and lowers blood pressure in genetically hypertensive rats. We conclude that TRPV1 activation by dietary capsaicin improves endothelial function. TRPV1-mediated increase in NO production may represent a promising target for therapeutic intervention of hypertension.
著者Yang DC, Luo ZD, Ma ST, Wong WT, Ma LQ, Zhong JA, He HB, Zhao ZG, Cao TB, Yan ZC, Liu DY, Arendshorst WJ, Huang Y, Tepel M, Zhu ZM
期刊名稱Cell Metabolism
出版年份2010
月份8
日期4
卷號12
期次2
出版社Elsevier (Cell Press)
頁次130 - 141
國際標準期刊號1550-4131
語言英式英語
Web of Science 學科類別Cell Biology; CELL BIOLOGY; Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

上次更新時間 2020-27-11 於 00:27