LED-activated pheophorbide a induces cellular destruction of colon cancer cells
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AbstractPheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta shows an important promise in the photodynamic therapy on malignant tumor. The present study investigated that LED-activated Pa induced the cellular destruction of colon cancer HT-29 cells. The results showed that Pa resulted in a drug-dose dependent photocytotoxicity in the HT-29 cells, meaning the photocytotoxicity of Pa depends on the drug concentration (0-2 mu M). We further investigated the apoptosis of the HT-29 cells 18 hours after photosensitization of Pa using a confocal laser scanning microscopy with Hoechst 33258 staining. These data demonstrated that LED-activated Pa could significantly induce the cellular destruction of the HT-29 cells.
All Author(s) ListXu CS, Leung AWN, Liu L, Xia XS
Journal nameLaser Physics Letters
Year2010
Month7
Day1
Volume Number7
Issue Number7
PublisherWiley-VCH Verlag: No OnlineOpen / IOP Publishing: Hybrid Open Access
Pages544 - 548
ISSN1612-2011
eISSN1612-202X
LanguagesEnglish-United Kingdom
Keywordsapoptosis; cellular destruction; colon cancer; LED; pheophorbide a; photodynamic action
Web of Science Subject CategoriesOptics; OPTICS; Physics; Physics, Applied; PHYSICS, APPLIED

Last updated on 2020-26-09 at 00:06