Dysregulation of cellular signaling in gastric cancer
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AbstractThe pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation of intracellular signaling pathways represents a common pathogenic mechanism and may be amenable to drug targeting. Multiple well-established oncogenic pathways, such as those mediated by cell cycle regulators, nuclear factor-kappa B, cyclooxygenase-2 and epidermal growth factor receptor are implicated in gastric carcinogenesis. Emerging evidence also underscores the importance of signaling pathways involved in the developmental process, including transforming growth factor-beta/bone morphogenetic protein signaling, Wnt/beta-catenin signaling, Hedgehog signaling and Notch signaling. Understanding their biological significance will provide a rational basis for drug development. Their relative importance and cross-talk in gastric carcinogenesis, however, are still not completely understood and warrant further investigation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListWu WKK, Cho CH, Lee CW, Fan DM, Wu KC, Yu J, Sung JJY
Journal nameCancer Letters
Volume Number295
Issue Number2
Pages144 - 153
LanguagesEnglish-United Kingdom
KeywordsCell signaling; Gastric cancer; Notch; Nuclear factor kappa B; Wnt
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-26-09 at 00:05