Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules
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摘要The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs. (C) 2010 Elsevier Ltd. All rights reserved.
著者Cheng SY, Yuen CWM, Lam PL, Gambari R, Wong RSM, Cheng GYM, Lai PBS, Tong SW, Chan KW, Lau FY, Kok SHL, Lam KH, Chui CH
期刊名稱Bioorganic and Medicinal Chemistry Letters
出版年份2010
月份7
日期15
卷號20
期次14
出版社Elsevier
頁次4147 - 4151
國際標準期刊號0960-894X
電子國際標準期刊號1464-3405
語言英式英語
關鍵詞Celecoxib; Chitosan; Cyclooxygenase 2; Oral administration
Web of Science 學科類別Chemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Organic; CHEMISTRY, ORGANIC; Pharmacology & Pharmacy

上次更新時間 2020-16-11 於 00:10