Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules
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AbstractThe use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs. (C) 2010 Elsevier Ltd. All rights reserved.
All Author(s) ListCheng SY, Yuen CWM, Lam PL, Gambari R, Wong RSM, Cheng GYM, Lai PBS, Tong SW, Chan KW, Lau FY, Kok SHL, Lam KH, Chui CH
Journal nameBioorganic and Medicinal Chemistry Letters
Year2010
Month7
Day15
Volume Number20
Issue Number14
PublisherElsevier
Pages4147 - 4151
ISSN0960-894X
eISSN1464-3405
LanguagesEnglish-United Kingdom
KeywordsCelecoxib; Chitosan; Cyclooxygenase 2; Oral administration
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Organic; CHEMISTRY, ORGANIC; Pharmacology & Pharmacy

Last updated on 2020-26-11 at 00:36