Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
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AbstractA physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-la markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-la inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListLum CT, Liu X, Sun RWY, Li XP, Peng Y, He ML, Kung HF, Che CM, Lin MCM
Journal nameCancer Letters
Volume Number294
Issue Number2
Pages159 - 166
LanguagesEnglish-United Kingdom
KeywordsCell migration; Gold(III) porphyrin 1a; Invasion; Metastasis; Nasopharyngeal carcinoma (NPC)
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2021-22-09 at 23:55