Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells
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AbstractCurcumin, a natural compound isolated from turmeric, may inhibit cell proliferation in various tumor cells through a mechanism that is not fully understood. The enhancer of zeste homolog 2 (EZH2) gene is overexpressed in human breast cancers with poor prognosis. In this study, we observed a dose- and time-dependent down-regulation of expression of EZH2 by curcumin that correlates with decreased proliferation in the MDA-MB-435 breast cancer cell line. The curcumin treatment resulted in an accumulation of cells in the G(1) phase of the cell cycle. Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (INK), extracellular signal-regulated kinase (ERK) and p38 kinase. These data suggest that an underlying mechanism of the MAPK pathway mediates the down-regulation of EZH2, thus contributing to the anti-proliferative effects of curcumin against breast cancer. (C) 2010 Elsevier B.V. All rights reserved.
All Author(s) ListHua WF, Fu YS, Liao YJ, Xia WJ, Chen YC, Zeng YX, Kung HF, Xie D
Journal nameEuropean Journal of Pharmacology
Detailed descriptionTo ORKTS: DOI: 10.1016/j.ejphar.2010.03.051
Year2010
Month7
Day10
Volume Number637
Issue Number1-3
PublisherElsevier
Pages16 - 21
ISSN0014-2999
eISSN1879-0712
LanguagesEnglish-United Kingdom
KeywordsBreast cancer; Curcumin; EZH2; Histone methyltransferase; MAPK
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-06-08 at 01:18