Proteasome inhibition: A new therapeutic strategy to cancer treatment
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AbstractThe ubiquitin-proteasome system is a major pathway for protein degradation. Targeting this pathway using proteasome inhibitors represents a novel approach for the treatment of cancer. Proteasome inhibitors lower cell proliferation and induce apoptosis in solid and hematologic malignancies through multiple mechanisms, including stabilization of cell cycle regulators and pro-apoptotic factors, stimulation of bone morphogenetic protein signaling, inhibition of protein translation, and sensitization to ligand-induced apoptosis. In this connection, proteasome inhibition activates macroautophagy, a compensatory protein degradation system, as well as other pro-survival signaling pathways. Inhibition of these auto-protective responses sensitizes cancer cells to the anti-proliferative effects of proteasome inhibitors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListWu WKK, Cho CH, Lee CW, Wu KC, Fan DM, Yu J, Sung JJY
Journal nameCancer Letters
Detailed descriptionTo ORKTS: doi: 10.1016/j.canlet2009.12.002
Year2010
Month7
Day1
Volume Number293
Issue Number1
PublisherElsevier
Pages15 - 22
ISSN0304-3835
eISSN1872-7980
LanguagesEnglish-United Kingdom
KeywordsAutophagy; Cancer; Proliferation; Proteasome inhibitor; Signaling
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-17-10 at 00:00