Role of warfarin pharmacogenetic testing in clinical practice
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AbstractChronic oral anticoagulation with warfarin is difficult to maintain within the therapeutic range and requires frequent monitoring and dose adjustments. Variations in two genes, VKORC1 and CYP2C9, have been associated with variation in warfarin metabolism among individuals. Patients with CYP2C9*2 and *3 variants have longer times to dose stabilization and are at higher risk of serious and life-threatening bleeding. VKORC1 polymorphisms significantly influence time to first therapeutic warfarin range, and variants in this gene determine low-, intermediate- and high-warfarin dose requirements. The prevalence of CYP2C9 and VKORC1 polymorphisms vary among different ethnic groups, and can account for over 30% of variance in warfarin dose. Recent studies suggest that the pharmacogenomics-guided dosing algorithm can accurately predict warfarin dosage and might reduce adverse events. We aim to review the pharmacogenetics of warfarin metabolism and the clinical role of genetic testing for warfarin therapy.
All Author(s) ListTan GM, Wu E, Lam YY, Yan BP
Journal namePharmacogenomics
Volume Number11
Issue Number3
PublisherFuture Medicine
Pages439 - 448
LanguagesEnglish-United Kingdom
Keywordsanticoagulation therapy; CYP2C9; pharmacogenetics; polymorphism; VKORC1; warfarin
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-24-09 at 00:13