Neutrophil-specific single-cell RNA-sequencing discovers a novel smad3-dependent immunosuppressor PRDM2 for promoting NSCLC
Refereed conference paper presented and published in conference proceedings


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AbstractThe functional role of tumor-associated neutrophils (TAN) in cancer progression is still controversial and largely unknown. Interestingly, Smad3-deficiency markedly increases TANs population in a syngeneic lung carcinoma mouse model LLC. We hypothesize that TGF-β1/Smad3 signaling may play an important role in TAN regulation and its function.
All Author(s) ListJ. CHUNG, T.L. Lee, K.F. To, H.Y. Lan, P.M.K. Tang
Name of ConferenceESMO Immuno-Oncology Virtual Congress 2020
Start Date of Conference09/12/2020
End Date of Conference12/12/2020
Place of ConferenceVirtual
Country/Region of ConferenceSwitzerland
Proceedings TitleAnnals of Oncology
Year2020
Month12
Volume Number31
Issue NumberSuppl 7
PublisherElsevier Inc.
PagesS1455 - S1455
ISSN0923-7534
eISSN1569-8041
LanguagesEnglish-United Kingdom

Last updated on 2022-15-01 at 00:37