Correlation between functional and anatomical assessments by multifocal electroretinography and optical coherence tomography in central serous chorioretinopathy
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摘要To evaluate the correlation between functional and anatomical assessments with multifocal electroretinography (mfERG) and optical coherence tomography (OCT) in patients with acute central serous chorioretinopathy (CSC). Thirty-four eyes of 34 patients with acute CSC underwent mfERG and OCT examinations. First-order mfERG N1 and P1 response amplitudes and latencies were analyzed. OCT parameters measured included central subretinal fluid (SRF) thickness, central retinal thickness, total central foveal thickness, vertical, and horizontal diameters of SRF, and macular volume. Correlation analyses were performed between best-corrected visual acuity (BCVA), mfERG parameters, and OCT measurements. Correlation analysis showed that logMAR BCVA was significantly correlated with mfERG N1 amplitudes of rings 1 and 2 (P = 0.006), N1 latency of ring 4 (P = 0.012), and P1 latency of ring 1 (P = 0.036). No significant correlation was observed between logMAR BCVA and any of the OCT measurements. For the correlation between mfERG parameters and OCT measurements, mfERG N1 and P1 latencies of the paracentral rings were significantly correlated with the central SRF thickness (P a parts per thousand currency sign 0.024), diameters of the SRF (P a parts per thousand currency sign 0.018), and macular volume (P a parts per thousand currency sign 0.030). MfERG responses but not OCT measurements correlated with logMAR BCVA in patients with acute CSC. The amount of SRF nonetheless correlated with the mfERG N1 and P1 latencies of the paracentral rings, suggesting that impairment in the conduction of electrical responses in the paracentral macula is proportional to the severity of serous macular detachment in CSC. MfERG and OCT can complement each other in the functional and anatomical assessments in CSC.
著者Yip YWY, Ngai JWS, Fok ACT, Lai RYK, Li HT, Lam DSC, Lai TYY
期刊名稱Documenta Ophthalmologica
出版年份2010
月份4
日期1
卷號120
期次2
出版社Springer Verlag (Germany)
頁次193 - 200
國際標準期刊號0012-4486
語言英式英語
關鍵詞Central serous chorioretinopathy; Multifocal electroretinography; Optical coherence tomography
Web of Science 學科類別Ophthalmology; OPHTHALMOLOGY

上次更新時間 2021-29-11 於 00:07