Olvanil: A non-pungent TRPV1 activator has anti-emetic properties in the ferret
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摘要Anti-emetic drugs such as the tachykinin NK(1) receptor antagonists are useful to control emesis induced by diverse challenges. Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity. However, pungent compounds are associated with undesirable effects including adverse actions on the cardiovascular system and on temperature homeostasis. In the present investigations using the ferret, we examine if the non-pungent vanilloid, olvanil, has useful anti-emetic properties without adversely affecting behaviour, blood pressure or temperature control. Olvanil (0.05-5 mg/kg, s.c.) was compared to the pungent vanilloid, resiniferatoxin (RTX; 0.1 mg/kg, s.c.), and to the anandamide reuptake inhibitor, AM404 (10 mg/kg, s.c.), for a potential to inhibit emesis induced by apomorphine (0.25 mg/kg, s.c.). copper sulphate (50 mg/kg, intragastric), and cisplatin (10 mg/kg, i.p.). Changes in blood pressure and temperature were also recorded using radiotelemetry implants.
著者Chu KM, Ngan MP, Wai MK, Yeung CK, Andrews PLR, du Sert NP, Rudd JA
期刊名稱Neuropharmacology
詳細描述To ORKTS: doi: 10.1016/j.neuropharm.2009.10.002
出版年份2010
月份2
日期1
卷號58
期次2
出版社Elsevier
頁次383 - 391
國際標準期刊號0028-3908
電子國際標準期刊號1873-7064
語言英式英語
關鍵詞Cisplatin; Emesis; Olvanil; Resiniferatoxin; TRPV1; Vanilloid
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

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