Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
Publication in refereed journal

香港中文大學研究人員

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其它資訊
摘要Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus gluconeogenesis and the branching between citrate cycle and glyoxylate bypass were all regulated by acetylation. This modulation is mainly controlled by a pair of lysine acetyltransferase and deacetylase, whose expressions are coordinated with growth status. Reversible acetylation of metabolic enzymes ensure that cells respond environmental changes via promptly sensing cellular energy status and flexibly altering reaction rates or directions. It represents a metabolic regulatory mechanism conserved from bacteria to mammals.
著者Wang QJ, Zhang YK, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao YF, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao SM, Zhao GP
期刊名稱Science
出版年份2010
月份2
日期19
卷號327
期次5968
出版社American Association for the Advancement of Science
頁次1004 - 1007
國際標準期刊號0036-8075
電子國際標準期刊號1095-9203
語言英式英語
Web of Science 學科類別Multidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

上次更新時間 2020-27-11 於 00:13