Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
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AbstractLysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus gluconeogenesis and the branching between citrate cycle and glyoxylate bypass were all regulated by acetylation. This modulation is mainly controlled by a pair of lysine acetyltransferase and deacetylase, whose expressions are coordinated with growth status. Reversible acetylation of metabolic enzymes ensure that cells respond environmental changes via promptly sensing cellular energy status and flexibly altering reaction rates or directions. It represents a metabolic regulatory mechanism conserved from bacteria to mammals.
All Author(s) ListWang QJ, Zhang YK, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao YF, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao SM, Zhao GP
Journal nameScience
Volume Number327
Issue Number5968
PublisherAmerican Association for the Advancement of Science
Pages1004 - 1007
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

Last updated on 2021-22-09 at 23:51