Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity
Publication in refereed journal
已正式接受出版

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Background:
Perfluorooctanoic acid (PFOA) is a compound used as an industrial surfactant in chemical processes worldwide. Population and cross-sectional studies have demonstrated positive correlations between PFOA levels and human health problems.
Objectives:
Many studies have focused on the hepatotoxicity and liver problems caused by PFOA, with little attention to remediation of these problems. As an antioxidant, vitamin C is frequently utilized as a supplement for hepatic detoxification.
Methods:
In this study, we use a mouse model to study the possible role of vitamin C in reducing PFOA-induced liver damage. Based on comparative transcriptomic and metabolomic analysis, we elucidate the mechanisms underlying the protective effect of vitamin C.
Results:
Our results show that vitamin C supplementation reduces signs of PFOA-induced liver damage including total cholesterol and triglyceride levels increase, liver damage markers aspartate, transaminase, and alanine aminotransferase elevation, and liver enlargement. Further, we show that the protective role of vitamin C is associated with signaling networks control, suppressing linoleic acid metabolism, reducing thiodiglycolic acid, and elevating glutathione in the liver.
Conclusion:
The findings in this study demonstrate, for the first time, the utility of vitamin C for preventing PFOA-induced hepatotoxicity.
出版社接受日期11.04.2021
著者Rong Li, Chao Guo, Xiao Lin, Ting Fung Chan, Min Su, Zhiyong Zhang, Keng Po Lai
期刊名稱Journal of Advanced Research
出版年份2021
國際標準期刊號2090-1232
電子國際標準期刊號2090-1224
語言美式英語

上次更新時間 2021-18-09 於 23:52