Effect of weight loss on the retinochoroidal structural alterations among patients with exogenous obesity
Publication in refereed journal



To evaluate the changes in the retinochoroidal vasculature in patients with exogenous obesity using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA).


In this prospective study, 60 patients diagnosed with obesity (47 males) (mean age: 46.47 +/- 10.9 years) were included, of which 30 patients underwent bariatric surgery (Group A), and 30 patients underwent conservative management (exercise/diet) (Group B). Parameters including choroidal thickness (CT), choroidal vascularity index (CVI) and retinal capillary density index (CDI) and arteriovenous ratio (AVR) were measured at the baseline and three months follow up. 30 eyes (30 age and gender-matched) of normal participants were included for comparison.


Baseline CT was lower in 60 participants with obesity compared to controls. Compared with normal subjects, subjects with obesity had higher mean CVI (0.66 +/- 0.02 versus 0.63 +/- 0.04; p<0.01), smaller FAZ area (0.26 +/- 0.07 versus 0.45 +/- 0.32; p<0.01), higher CDI (superficial plexus: 0.7 +/- 0.04 versus 0.68 +/- 0.06; p = 0.04, deep plexus: 0.38 +/- 0.02 versus 0.35 +/- 0.06; p = 0.01), and lower AVR (0.68 +/- 0.05 versus 0.70 +/- 0.03 versus; p<0.01). At 3-month after intervention, CT showed a significant increase in participants from Group A (329.27 +/- 79 mu m; p<0.01) but not in Group B from baseline. No significant change was noted in CVI or CDI at 3-month in either group compared to baseline. AVR significantly increased in Group B (p = 0.03).


Subclinical changes in retinochoroidal vasculature occurs in participants with exogenous obesity compared to healthy subjects. Surgical intervention (bariatric surgery) may have a favorable outcome on the choroidal thickness in these patients.
著者Agarwal A, Saini A, Mahajan S, Agrawal R, Cheung CY, Rastogi A, Gupta R, Wang YM, Kwan M, Gupta V, OCTA Study Group
期刊名稱PLoS ONE
出版社Public Library of Science

上次更新時間 2021-26-09 於 01:46