Nucleic Acid-Based Technologies Targeting Coronaviruses
Publication in refereed journal

替代計量分析
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其它資訊
摘要The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
出版社接受日期26.11.2020
著者Le TK, Paris C, Khan KS, Robson F, Ng WL, Rocchi P
期刊名稱Trends in Biochemical Sciences
出版年份2021
月份5
卷號46
期次5
出版社ELSEVIER SCIENCE LONDON
頁次351 - 365
國際標準期刊號0968-0004
電子國際標準期刊號1362-4326
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology;Biochemistry & Molecular Biology

上次更新時間 2021-17-09 於 00:39